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pentobarbital will lower the level or result of prednisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital raises effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Warning/Monitor. Coadministration of ifosfamide with CYP2B6 inducers could raise metabolism of ifosfamide to its metabo